EXPEDITIOUS AND STEREOSELECTIVE SYNTHESIS OF CHIRAL TRANS-BETA-HYDROXY-DELTA-LACTONE SYSTEMS

Authors
MIYAZAWA M MATSUOKA E SASAKI S OONUMA S MARUYAMA K MIYASHITA M
Citation
M. Miyazawa et al., EXPEDITIOUS AND STEREOSELECTIVE SYNTHESIS OF CHIRAL TRANS-BETA-HYDROXY-DELTA-LACTONE SYSTEMS, Chemistry Letters, (2), 1998, pp. 109-110
Citations number
16
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
2
Year of publication
1998
Pages
109 - 110
Database
ISI
SICI code
0366-7022(1998):2<109:EASSOC>2.0.ZU;2-A
Abstract
Expeditious and stereoselective synthesis of chiral trans-beta-hydroxy -delta-lactone systems starting from gamma,delta-epoxy acrylates is de scribed which involves the regioselective ring opening of an epoxide a nd the intramolecular conjugate addition of a hemiacetal alkoxide anio n of delta-hydroxy-alpha,beta-unsaturated esters as key steps.