SYNTHESIS OF PHOSPHATIDYLCHOLINE HAVING A VERY LONG-CHAIN POLYUNSATURATED FATTY-ACID

Authors
HAIDER SS TANAKA M ALAM MK NAKAJIMA S BABA N SHIMIZU S
Citation
Ss. Haider et al., SYNTHESIS OF PHOSPHATIDYLCHOLINE HAVING A VERY LONG-CHAIN POLYUNSATURATED FATTY-ACID, Chemistry Letters, (2), 1998, pp. 175-176
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
2
Year of publication
1998
Pages
175 - 176
Database
ISI
SICI code
0366-7022(1998):2<175:SOPHAV>2.0.ZU;2-4
Abstract
A phosphatidylcholine 9 bearing icosadienoyl and docosahexaenoyl group s at the 1- and 2-positions respectively was synthesized. The syntheti c route involves carbon chain elongation of linoleic acid via malonic ester synthesis, preparation of lyso-phosphatidylcholine via lipase-ca talyzed mono-acylation of 2-O-methoxyethoxymethylglycerol and phosphod iester synthesis, and finally DCC-mediated esterification.