Ih. Khan et al., COMPARING OUTCOMES IN RENAL REPLACEMENT THERAPY - HOW SHOULD WE CORRECT FOR CASE-MIX, American journal of kidney diseases, 31(3), 1998, pp. 473-478
The need to evaluate the effectiveness of clinical practice to justify
expensive therapy in the face of financial constraints in all areas o
f health care delivery makes it necessary to identify groups of patien
ts who are likely to benefit most from treatment. Various risk stratif
ication methods have been used for analyzing survival probabilities fo
r patients receiving renal replacement therapy. Complicated risk strat
ification methods produce large numbers of risk groups of small sizes,
which makes comparison between individual centers difficult. We compa
red three simple methods of risk stratification, that divided patients
into low-, medium-, and high-risk groups, in a cohort of 1,407 patien
ts who commenced renal replacement therapy in five European countries
during a 7-year period. Method 1 considered age (>55 years) and diabet
es alone; method 2 used a higher age limit (>70 years) and comorbid il
lnesses, including those other than diabetes; and method 3 used only t
he number of comorbidities (none, 1, or greater than or equal to 2) fo
r stratification. Kaplan-Meier survival curves were constructed for co
mparison between risk groups and Cox's regression model used to assess
strength of relationship with mortality. Although patient survival wa
s significantly different between the low-, medium-, and high-risk gro
ups using all three methods, Cox's regression analysis showed that met
hod 2 provided the greatest discrimination between risk groups. In pre
dicting mortality, method 2 (based on comorbidities and age) showed th
e highest sensitivity and specificity (84% and 80%, respectively) comp
ared with method 1 (80% and 74%) and method 3 (64% and 82%). Validatio
n of this approach in other populations in a prospective study is requ
ired before this method, which takes into account the influences of bo
th age and comorbidity for risk stratification, can be used for compar
ing survival data and for presenting results of renal replacement ther
apy. (C) 1998 by the National Kidney Foundation, Inc.