VASCULAR ABNORMALITIES IN SCLERODERMA

Vascular abnormalities represent a fundamental event in the pathogenes is of systemic sclerosis. This review focuses on key observations that support this view and builds a framework with which to clarify our un derstanding of how endothelial cell damage may trigger a self-fueling process ending in pathological tissue fibrosis in those susceptible to scleroderma. The studies reviewed in this article pertain to systemic sclerosis patients. Copyrights (C) 1998 by W.B. Saunders Company.