Modern treatment of complex midfacial defects has evolved over the pas
t 5 years, primarily with the advent of reliable vascularized bone fla
ps and osseointegrated implants. To determine the effectiveness of the
se advances, 26 consecutive patients with complex midfacial defects tr
eated from 1991 through 1995 with immediate muscle-flap coverage were
evaluated. The etiology of the defect included neoplasm (n = 23) and t
rauma (n = 3). Seventy eight percent of the patients received adjuvant
radiation therapy. Follow-up ranged from 3 months to 4 years, with a
mean of 18 months. Twenty-three patients (88 percent) were reconstruct
ed with a single major procedure. All patients had free-flap reconstru
ction, and 100 percent of the flaps survived. Late tumor recurrence wa
s seen in 5 of 23 patients (22 percent) and was detected promptly. Aes
thetic and functional results were rated good or excellent in 77 and 8
8 percent of the patients, respectively, as determined by patient ques
tionnaires and physical examinations. Fourteen of 18 patients (78 perc
ent) undergoing partial or complete alveolar ridge resection received
dental rehabilitation, 43 percent of whom received osseointegrated imp
lants into either a bone flap or remaining native bone. Osseointegrate
d implants were inset during the initial reconstruction 50 percent of
the time. A treatment algorithm for free-flap selection based on the s
ize of the defect and the bony requirement for reconstruction is prese
nted. Bony restoration is only required in those areas where osseointe
grated implants need to be placed. In such cases, the fibula osteocuta
neous free flap is the flap of choice. Otherwise, soft-tissue flaps ar
e selected based on wound size. Immediate free-flap coverage provides
effective, single-stage treatment, both aesthetically and functionally
, for complex midfacial defects.