MODEST RELEASE OF ADIPSIN FACTOR-D BY LIPOSUCTION WHEN USING THE SUPERWET OR TUMESCENT TECHNIQUE

Human adipsin is recognized to be identical to factor D, which plays a n important role in activation of the alternative complement path way. Since adipsin/factor D is present in high amounts in adipose tissue, liposuction theoretically could result in an increased release of this serine protease into the bloodstream. In the present study, adipsin/f actor D was measured in 22 patients undergoing syringe-assisted liposu ction using the superwet or tumescent technique. Despite a relatively high mean aspirate volume (2648 mi), only avery modest increase in adi psin/factor D concentration was found during liposuction. All values b efore, during, and after liposuction were within the range found in he althy blood donors. Furthermore, there was no correlation between adip sin/factor D values and C3 activation products. We conclude that lipos uction with the present technique results in a very modest release of adipsin/factor D that is not associated with increased complement acti vation.