This study investigates the process of stripping the adventitia off a
blood vessel. which is a normal procedure prior to performing a microv
ascular anastomosis. In five rats, the common carotid and the superfic
ial femoral arteries of one side were stripped sharply, whereas the ar
teries of the other side were left unstripped to serve as controls. In
a further set of five rats, the arteries were stripped bluntly. Immed
iately following stripping, experimental and control arterial segments
were removed. Histology of cross sections of the segments was studied
. In no case was there complete removal of the adventitia. When stripp
ed and control arterial sections were compared, no significant differe
nce between cross-sectional adventitial areas could be demonstrated. M
orphologic study revealed that stripping mainly removes large collagen
fibers from the adventitia. The small collagen fibrils that are still
in place fan our in such a way that although considerable tissue is r
emoved, the volume that the adventitia occupies remains the same. Stri
pping the adventitia does not cause complete removal of the adventitia
, and in this study no significant reduction in the adventitial volume
could be found. Stripping does, however, allow a better view of the c
ut edge of the vessel wail under an operating microscope. Since blunt
stripping could cause damage to other vessel wall layers, sharp stripp
ing is to be preferred.