Iwr. Holten et al., THE APERT SYNDROME HAND - PATHOLOGICAL ANATOMY AND CLINICAL MANIFESTATIONS, Plastic and reconstructive surgery, 99(6), 1997, pp. 1681-1687
The Apert syndrome hand demonstrates many typical clinical features in
cluding syndactyly, symbrachyphalangism, and growth disturbances. This
is due to the grossly abnormal anatomy of both the skeletal and soft-
tissue structures associated with a progressive disease process. This
paper presents a clinical, radiologic, and histologic analysis of the
Apert syndrome hand anatomy and correlates it with the clinical manife
stations. It also links hand and craniofacial dysplasia to other regio
ns of the skeleton as well as the overall disease process. From our an
alysis, we conclude that there is a genetic anomaly causing variable a
nd uncoordinated differentiation of the mesenchyme at the time of embr
yologic separation into its various skeletal components, particularly
in the distal limb bud and craniofacial skeleton. This disease process
continues postnatally in endochondral bone growth center malformation
and malfunction as well as ectopic cartilage ossification in soft tis
sues. We discuss the role of abnormal musculotendinous anatomy and alt
ered biomechanical forces in relation to these processes.