CONCURRENT MONITORING OF EEG AND PERFORMANCE IN THE COMMON MARMOSET -A METHODOLOGICAL APPROACH

A model has been developed in a nonhuman primate, the common marmoset (Callithrix jacchus), which should enable the study of long term effec ts of compounds with potentially psychoactive properties. The techniqu e facilitates concurrent monitoring of both behavioral and electrophys iological parameters while animals remain in their home cages. Subject s were trained to perform tests from a neuropsychological test battery (The Cambridge Neuropsychological Test Automated Battery, CANTAB) in which they learned to discriminate between pairs of stimuli presented on a touch sensitive computer screen. Single channel cortical electroe ncephalography (EEG) by radiotelemetry was simultaneously recorded whi le behavioral testing took place. (C) 1998 Elsevier Science Inc.