BUSPIRONE IN THE MANAGEMENT OF ANXIETY AND IRRITABILITY IN CHILDREN WITH PERVASIVE DEVELOPMENTAL DISORDERS - RESULTS OF AN OPEN-LABEL STUDY

Background: We evaluated the efficacy and safety of buspirone in the m anagement of anxiety and irritability in children with pervasive devel opmental disorders (PDD). Method: Twenty-two subjects, 6 to 17 years o ld, with DSM-III-R diagnosed PDD-NOS (N = 20) or autistic disorder (N = 2), were included. They were treated with buspirone in dosages rangi ng from 15 to 45 mg/day in an open-label trial lasting 6 to 8 weeks. R esponders continued buspirone treatment and were followed up for up to 12 months. Results: Nine subjects had a marked therapeutic response a nd 7 subjects a moderate response on the Clinical Global Impressions ( CGI) scale after 6 to 8 weeks of treatment. Side effects were minimal, except for 1 patient who developed abnormal involuntary movements. Co nclusion: These results suggest that buspirone may be useful for treat ing symptoms of anxiety and irritability in children with PDD.