VACCINATION AGAINST SCHISTOSOMIASIS - THE CASE FOR LUNG-STAGE ANTIGENS

The development of an effective vaccine against human schistosomiasis remains a highly desirable yet elusive goal. In this article, Adrian M ountford and Richard Harrop focus attention on an approach that aims t o identify proteins from Schistosoma mansoni that are capable of stimu lating protective Th1 cell-mediated immune responses. They propose tha t the most likely source of such antigens is the lung-stage schistosom ulum.