NUCLEAR-MAGNETIC-RESONANCE SPECTRAL-ANALYSIS AND CONFORMATIONAL PROPERTIES OF L-9,9A,10,11-TETRAHYDRO-4H-INDOLO[4,3-AB]CARBAZOLE

The structure of 11-benzoyl-9,9a,10,11-tetrahydro-4H-indolo [4,3-ab] c arbazole, a candidate molecule to possess significant antitumor or ant imicrobial activity, was elucidated using a combination of one-dimensi onal and two-dimensional nuclear magnetic resonance (NMR) techniques. Its conformational properties were studied using a combination of two- dimensional NOESY spectroscopy and molecular modeling. Such informatio n will be of aid to synthetic chemists who aim to develop derivatives of this structure. It may also provide information about the stereoele ctronic requirements that govern their activities. (C) 1998 Elsevier S cience B.V.