ELECTROANALYTICAL STUDY OF NIFEDIPINE USING ACTIVATED GLASSY-CARBON ELECTRODE

The electrochemical properties of nifedipine have been investigated in aqueous solution by linear sweep and cyclic voltammetry. The method i s based both on the reduction and on the oxidation of the drug at a gl assy carbon electrode activated by applying a new pre-treatment. The v oltammograms of nifedipine on pH, concentration and scan rate have bee n carefully examined. Both the electroreduction and electrooxidation o f nifedipine allow its determination at pH 1.5 in the concentration ra nge of 2 x 10(-5)-6 x 10(-4) M and 8 x 10(-5)-1 x 10(-3) M, respective ly. The method has been applied to commercial samples (tablets and cap sules). (C) 1998 Elsevier Science B.V.