APPLICATIONS OF POLARIZATION TRANSFER AND INDIRECT DETECTION NMR SPECTROSCOPIC METHODS BASED ON P-31 IN ORGANIC AND ORGANOMETALLIC CHEMISTRY

This review will analyse state-of-the-art NMR experiments of polarizat ion transfer and indirect detection based on phosphorus-31 and their a pplications in organic and organometallic chemistry. Triple resonance NMR spectroscopy based on phosphorus-31 as a source of signal intensit y enhancement and/or detection, is currently a very well established t ool in structural studies. Nowadays, improvements in NMR equipment: al low to perform these pulse sequences on a routine basis. Initially, th ese techniques were developed to measure the chemical shift and coupli ng constants of insensitive nuclei scalarly coupled to phosphorus, but lacking a J coupling to protons. The main focus was devoted to metal nuclei of organotransition complexes, including the measurement of lon gitudinal relaxation times. This NMR methodology has been also very fr uitful in providing structural information through P-31 correlations w ith more common nuclei such as Li-6, C-13, N-15, and O-17. Recent appl ications of phosphorus-detection cover the correlation of transition m etal NMR parameters with chemical properties (catalytic activity, stab ility constants, reaction rates, etc.), of particular relevance to ded uce structure-reactivity relationships.