CAN PATIENTS WITH CHRONIC NEUROPATHIC PAIN BE CURED BY ACUTE ADMINISTRATION OF THE NMDA RECEPTOR ANTAGONIST AMANTADINE

Authors
EISENBERG E PUD D
Citation
E. Eisenberg et D. Pud, CAN PATIENTS WITH CHRONIC NEUROPATHIC PAIN BE CURED BY ACUTE ADMINISTRATION OF THE NMDA RECEPTOR ANTAGONIST AMANTADINE, Pain, 74(2-3), 1998, pp. 337-339
Citations number
16
Categorie Soggetti
Anesthesiology,Neurosciences,"Clinical Neurology
Journal title
Pain → ACNP
ISSN journal
03043959
Volume
74
Issue
2-3
Year of publication
1998
Pages
337 - 339
Database
ISI
SICI code
0304-3959(1998)74:2-3<337:CPWCNP>2.0.ZU;2-C
Abstract
The treatment of neuropathic pain remains a challenge as it rarely lea ds to long-term relief of symptoms. We report three patients with chro nic neuropathic pain, in whom acute administration of the N-methyl-D-a spartate (NMDA) receptor antagonist amantadine resulted in complete re solution of symptoms, presumably due to termination the central 'wind- up' phenomenon. (C) 1998 International Association for the Study of Pa in. Published by Elsevier Science B.V.