ALKYLATION AND DECARBOXYLATION OF ETHYL 2-FLUORO-3-OXOBUTANOATE AS A ROUTE TO FUNCTIONALIZED ALPHA-FLUORO-KETONES

Authors
HUTCHINSON J SANDFORD G VAUGHAN JFS
Citation
J. Hutchinson et al., ALKYLATION AND DECARBOXYLATION OF ETHYL 2-FLUORO-3-OXOBUTANOATE AS A ROUTE TO FUNCTIONALIZED ALPHA-FLUORO-KETONES, Tetrahedron, 54(12), 1998, pp. 2867-2876
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
12
Year of publication
1998
Pages
2867 - 2876
Database
ISI
SICI code
0040-4020(1998)54:12<2867:AADOE2>2.0.ZU;2-T
Abstract
Alkylation and decarboxylation of alpha-fluoro-beta-ketoesters such as ethyl 2-fluoro-3-oxobutanoate offers a versatile route to a range of fluoro-ketoalkenes, demonstrating the synthetic utility of using alpha -fluoro-beta-ketoesters as synthons for the preparation of synthetical ly more sophisticated selectively fluorinated systems. (C) 1998 Elsevi er Science Ltd. All rights reserved.