HODGKINS-DISEASE OF DONOR ORIGIN AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR MYELOGENEOUS CHRONIC LEUKEMIA

Secondary malignancies (lymphomas, leukemias, and solid tumors) occurr ing after bone marrow transplantation are now more frequently reported , as the patients surviving the early phase of the graft and remaining free of their original disease are more numerous. Besides early Epste in-Barr virus-associated B-cell lymphoproliferative diseases, which ar e the most common type and most often of donor origin, few late-occurr ing lymphomas have been described that might represent a distinct enti ty. We report here a case of Hodgkin's disease developing 8 years afte r allogeneic bone marrow transplantation for chronic myelogeneous leuk emia, Only two Hodgkin's diseases after allogeneic bone marrow transpl antation have been reported in the literature so far. The case we repo rt is of interest because of its donor origin and its association with Epstein-Barr virus infection.