SERUM URIC-ACID IS A STRONG PREDICTOR OF STROKE IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS

Background and Purpose-Patients with non-insulin-dependent diabetes me llitus (NTT)DM) are at increased risk for stroke. Hyperuricemia is a c ommon finding in NIDDM, but its significance as an independent risk fa ctor for cardiovascular disease has remained uncertain. Therefore, we investigated serum urate as a predictor of stroke in NIDDM patients fr ee of clinical nephropathy (ie, with a serum creatinine level of less than or equal to 120 mu mol/L). Methods-In this population-based study , cardiovascular risk factors were determined in 1017 patients (551 me n and 466 women) with NIDDM, aged 45 to 64 years at baseline. The pati ents were followed up for 7 pears with respect to stroke events. Resul ts-During the follow-up period, 31 NIDDM patients (12 men [2.2%] and 1 9 women [4.1%]) died from stroke and 114 NIDDM patients (55 men [10.0% ] and 59 women [12.7%]) had a fatal or nonfatal stroke. The incidence of stroke increased significantly by quartiles of serum uric acid leve ls (P<.001). High uric acid level (above the median value of >295 mu m ol/L) was significantly associated with the risk of fatal and nonfatal stroke by Cox regression analysis (hazard ratio, 1.93 [1.30 to 2.86]; P=.001). This association remained statistically significant even aft er adjustment for all cardiovascular risk factors (hazard ratio, 1.91 [1.24 to 2.94[; P=.003). Conclusions-Our results indicate that hyperur icemia is a strong predictor of stroke events in middle-aged patients with NIDDM independently of other cardiovascular risk factors.