ROLE OF B-CELL AND FC-RECEPTORS IN THE SELECTION OF T-CELL EPITOPES

The role of specific receptors in antigen internalization and presenta tion to helper T lymphocytes has been known for more than ten years. H owever, recent work indicates that internalization may not always be s ufficient for antigen presentation. Indeed, antigen receptors such as B-cell receptors and Fc receptors may also be involved in the post-end ocytic transport events that determine selectively the delivery of ant igens to different endocytic compartments and thereby the presentation of different T-cell epitopes.