Objective. We aimed to determine the complex of symptoms which has the
highest predictive value for the diagnosis of influenza. Method. A qu
estionnaire study with questions regarding the symptomatology of influ
enza among patients aged 60 and older (n = 1838). Thirty-four particip
ating GPs recorded the symptomatology of patients who came to their ge
neral practice with influenza-like complaints. The validity of the dia
gnostic conclusion of the GP, as well as the diagnostic validity of th
e criteria of the International Classification of Health Problems in P
rimary Care (ICHPPC-2) and the Sentinel Stations in The Netherlands, w
as determined with the help of the predictive value and odds ratio, us
ing serologically confirmed influenza as the gold standard. The same m
ethod was used to determine which complex of symptoms has the highest
predictive value for influenza. The results were verified using logist
ic regression analysis. Results. The predictive value of the diagnosti
cs of the GP amounted to 35%. The predictive values of the diagnostics
according to the criteria of the two classification methods were 24%
(Sentinel Stations) and 18% (ICHPPC-2). Of the individual symptoms, th
e combination of fever, coughing and acute onset had the highest predi
ctive value (30.3%) for the diagnosis of influenza. Conclusion. It is
recommended that the criteria of the Sentinel Stations in The Netherla
nds and the ICHPPC-2 be adapted in the following way: influenza is lik
ely if, out of the entire complex of symptoms, at least fever, coughin
g and an acute onset occur.