SURVIVAL OF TRANSFUSED CD18-POSITIVE GRANULOCYTES AND THEIR CHEMILUMINESCENT RESPONSE IN A HEIFER WITH LEUKOCYTE ADHESION DEFICIENCY

Authors
NAGAHATA H SAKURAI N MATSUKI S MIURA T NIOKA K KOCIBA GJ
Citation
H. Nagahata et al., SURVIVAL OF TRANSFUSED CD18-POSITIVE GRANULOCYTES AND THEIR CHEMILUMINESCENT RESPONSE IN A HEIFER WITH LEUKOCYTE ADHESION DEFICIENCY, Journal of veterinary medical science, 60(2), 1998, pp. 261-262
Citations number
6
Categorie Soggetti
Veterinary Sciences
Journal title
Journal of veterinary medical science → ACNP
ISSN journal
09167250
Volume
60
Issue
2
Year of publication
1998
Pages
261 - 262
Database
ISI
SICI code
0916-7250(1998)60:2<261:SOTCGA>2.0.ZU;2-1
Abstract
Granulocyte transfusion (GT) was performed in an 8-month-old heifer wi th leukocyte adhesion deficiency (BLAD) to monitor the changes in tran sfused CD18-positive neutrophils and associated neutrophil chemilumine scent (CL) response in beta(2)-integrin-deficient host. The CD18-posit ive neutrophils were detected in blood from the BLAD heifer during the first 3 hr after 2.6 x 10(9) cells were infused by GT, and disappeare d by 5 hr after GT. The CL response of neutrophils was increased 1.7 t o 2.8-fold in the BLAD heifer during the first 3 hr after GT, thereaft er CL response decreased gradually from 2 to 5 hr after GT.