RATE OF DEPROTONATION OF A SIMPLE KETONE BY LITHIUM DIISOPROPYLAMIDE

Authors
MAJEWSKI M NOWAK P
Citation
M. Majewski et P. Nowak, RATE OF DEPROTONATION OF A SIMPLE KETONE BY LITHIUM DIISOPROPYLAMIDE, Tetrahedron letters, 39(13), 1998, pp. 1661-1664
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
13
Year of publication
1998
Pages
1661 - 1664
Database
ISI
SICI code
0040-4039(1998)39:13<1661:RODOAS>2.0.ZU;2-4
Abstract
Rate studies on deprotonation of a simple ketone (R-2,2,6-trimethylcyc lohexanone) with lithium diisopropylamide are described. The data are consistent with the reaction being first order in ketone and half orde r in the base, corresponding to the rate equation: v = k[ketone][LDA]( 1/2). (C) 1998 Elsevier Science Ltd. All rights reserved.