EVALUATION OF MONOMETHOXYTRITYL AND DIMETHOXYTRITYL AS ORTHOGONAL AMINO PROTECTING GROUPS IN FMOC SOLID-PHASE PEPTIDE-SYNTHESIS

Amino acid derivatives protected at the alpha- or side chain amino fun ction with mono- as well as dimethoxytrityl were successfully prepared by a one-step procedure. These derivatives were evaluated for their u tilization in solid phase peptide synthesis (SPPS), particularly with respect to the selective detritylation in the presence of other acid l abile protecting groups to allow for the preparation of multiple, bran ched or cyclized peptide structures as well as for site specific post- assembly manipulations. (C) 1998 Elsevier Science Ltd. All rights rese rved.