OMEPRAZOLE IN INFANTS WITH CIMETIDINE-RESISTANT PEPTIC ESOPHAGITIS

Twelve neurologically normal infants (age 2.9 +/- 0.9 months) with pep tic esophagitis (grade 2) who did not respond to cimetidine (in additi on to positioning, cis-apride, and Gaviscon) were treated with omepraz ole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazol e was evaluated in all infants by clinical assessment and endoscopy be fore and after treatment and by 24-hour gastric pH monitoring during t reatment in seven infants. Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intr agastric acidity.