Twelve neurologically normal infants (age 2.9 +/- 0.9 months) with pep
tic esophagitis (grade 2) who did not respond to cimetidine (in additi
on to positioning, cis-apride, and Gaviscon) were treated with omepraz
ole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazol
e was evaluated in all infants by clinical assessment and endoscopy be
fore and after treatment and by 24-hour gastric pH monitoring during t
reatment in seven infants. Omeprazole therapy led to a marked decrease
in symptoms, endoscopic and histologic signs of esophagitis, and intr
agastric acidity.