COMBINATION OF LC-MS AND LC-NMR AS A TOOL FOR THE STRUCTURE DETERMINATION OF NATURAL-PRODUCTS

Authors
VOGLER B KLAIBER I ROOS G WALTER CU HILLER W SANDOR P KRAUS W
Citation
B. Vogler et al., COMBINATION OF LC-MS AND LC-NMR AS A TOOL FOR THE STRUCTURE DETERMINATION OF NATURAL-PRODUCTS, Journal of natural products, 61(2), 1998, pp. 175-178
Citations number
7
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
2
Year of publication
1998
Pages
175 - 178
Database
ISI
SICI code
0163-3864(1998)61:2<175:COLALA>2.0.ZU;2-9
Abstract
Application of both LC-MS and LC-NMR to a partially purified extract o f Vernonia fastigiata led to the direct identification of antibacteria l sesquiterpene lactones 1-9 without isolation of individual compounds . The rapid structural analysis of both major and minor components of this class of compounds demonstrated the power of structure-guided scr eening as a complementary method to assay-guided screening.