LIMONOIDS SHOWING SELECTIVE TOXICITY TO DNA REPAIR-DEFICIENT YEAST AND OTHER CONSTITUENTS OF TRICHILIA-EMETICA

Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5),and Tr-B (7) a nd the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B show ed selective inhibitory activity toward DNA repair-deficient yeast mut ants. The isolation, structure elucidation, C-13 NMR spectral assignme nts, and biological activities of:these compounds are reported.