FOMITELLIC ACIDS, TRITERPENOID INHIBITORS OF EUKARYOTIC DNA-POLYMERASES FROM A BASIDIOMYCETE, FOMITELLA-FRAXINEA

Authors
TANAKA N KITAMURA A MIZUSHINA Y SUGAWARA F SAKAGUCHI K
Citation
N. Tanaka et al., FOMITELLIC ACIDS, TRITERPENOID INHIBITORS OF EUKARYOTIC DNA-POLYMERASES FROM A BASIDIOMYCETE, FOMITELLA-FRAXINEA, Journal of natural products, 61(2), 1998, pp. 193-197
Citations number
19
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
2
Year of publication
1998
Pages
193 - 197
Database
ISI
SICI code
0163-3864(1998)61:2<193:FATIOE>2.0.ZU;2-Y
Abstract
Four new triterpenoid compounds, 1-4, were isolated from the mycelium of a basidiomycete, Fomitella fraxinea, and their structures determine d by spectroscopic analyses. Compounds 1-5 inhibited calf DNA polymera se alpha and rat DNA polymerase beta, with respective minimum inhibito ry concentration (MIC) ranges of 35-75 and 90-130 mu M.