ISOLATION OF 1-METHYLHERBIPOLINE SALTS OF HALISULFATE-1 AND OF SUVANINE AS SERINE-PROTEASE INHIBITORS FROM A MARINE SPONGE, COSCINODERMA-MATHEWSI

Authors
KIMURA J ISHIZUKA E NAKAO Y YOSHIDA WY SCHEUER PJ KELLYBORGES M
Citation
J. Kimura et al., ISOLATION OF 1-METHYLHERBIPOLINE SALTS OF HALISULFATE-1 AND OF SUVANINE AS SERINE-PROTEASE INHIBITORS FROM A MARINE SPONGE, COSCINODERMA-MATHEWSI, Journal of natural products, 61(2), 1998, pp. 248-250
Citations number
11
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
2
Year of publication
1998
Pages
248 - 250
Database
ISI
SICI code
0163-3864(1998)61:2<248:IO1SOH>2.0.ZU;2-O
Abstract
Bioassay-guided isolation of serine protease inhibitors from a marine sponge, Coscinoderma mathewsi, has yielded 1-methylherbipoline salts o f halisulfate-1 and of suvanine. Structures of these compounds were id entified by spectroscopic analyses and literature data. Antithrombin a nd antitrypsin activity was determined.