NONLINEAR PHARMACOKINETICS OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR IN 3 ANIMAL SPECIES - A COMPARISON OF MATHEMATICAL-MODELS

A recent study presented plasma concentrations of tissue-type plasmino gen activator in three different animal species and at several differe nt dose levels. A three-compartment mammillary model with capacity-lim ited elimination (of Michaelis-Menten form) was postulated to describe the data. In the present study, several alternative model structures are examined with the view of determining whether better fits can be o btained, whether linear models are significantly worse than nonlinear models, and whether all three compartments are really necessary. (C) 1 998 John Wiley & Sons, Ltd.