NOVEL SITE-SPECIFIC DNA ENDONUCLEASES

Authors
AGGARWAL AK WAH DA
Citation
Ak. Aggarwal et Da. Wah, NOVEL SITE-SPECIFIC DNA ENDONUCLEASES, Current opinion in structural biology, 8(1), 1998, pp. 19-25
Citations number
40
Categorie Soggetti
Cell Biology",Biology
Journal title
Current opinion in structural biology → ACNP
ISSN journal
0959440X
Volume
8
Issue
1
Year of publication
1998
Pages
19 - 25
Database
ISI
SICI code
0959-440X(1998)8:1<19:NSDE>2.0.ZU;2-O
Abstract
Site-specific hydrolysis of DNA is common to many biological processes . Three new structures, FokI, I-Crel and PI-SceI, were reported in the past year, providing the first view of type IIs endonucleases and hom ing endonucleases. Together, they reveal an extraordinary set of new m echanisms by which endonucleases target the hydrolysis of specific DNA sequences.