GASTROINTESTINAL ALCOHOL-DEHYDROGENASE

Alcohol dehydrogenase (ADH) consists of a family of isozymes that conv ert alcohols to their corresponding aldehydes using NAD(+) as a cofact or The metabolism of ethanol by gastrointestinal ADH isozymes results in the production of acetaldehyde, a highly toxic compound that binds to cellular protein and DNA if not further metabolized to acetate by a cetaldehyde dehydrogenase isozymes. Acetaldehyde seems to be involved in ethanol-associated cocarcinogenesis. The metabolism of retinol and the generation of retinoic acid is a function of class I and class IV ADH, and its inhibition by alcohol may lead to an alteration of epithe lial cell differentiation and cell growth and may also be involved in ethanol-associated gastrointestinal cocarcinogenesis.