A NOVEL LONG-ACTING VIP ANALOG IN THE GUINEA-PIG TRACHEA IN-VITRO

Authors
YOSHIHARA S LINDEN A KASHIMOTO K WATANABE S
Citation
S. Yoshihara et al., A NOVEL LONG-ACTING VIP ANALOG IN THE GUINEA-PIG TRACHEA IN-VITRO, Peptides, 19(3), 1998, pp. 593-597
Citations number
21
Categorie Soggetti
Biology
Journal title
Peptides → ACNP
ISSN journal
01969781
Volume
19
Issue
3
Year of publication
1998
Pages
593 - 597
Database
ISI
SICI code
0196-9781(1998)19:3<593:ANLVAI>2.0.ZU;2-F
Abstract
The relaxant effect of a novel VIP analog, [Arg(15,20,21)Leu(17)]-VIP- Gly-Lys-Arg-NH2 was compared with that of the original VIP in the same guinea pig trachea precontracted by carbachol in vitro. The VIP analo g caused significantly and concentration-dependent relaxation similari ly to the original VIP. In contrast to the original VIP, the VIP analo g demonstrated a slow onset and offset of action, with more than 90% o f its maximum relaxation remaining 6 h after administration. Peptidase inhibition by captopril and phosphoramidon increased the relaxant eff ect and duration of action for original VIP but not for the VIP analog . (C) 1998 Elsevier Science Inc.