This paper focuses on interspecies differences in the prevalence and b
iological behavior of selected neoplasms of dogs and cats. In many ins
tances the naturally occurring neoplasms of dogs and cats exhibit spec
ies-specific biological behavior. In contrast to dogs, bladder tumors
occur infrequently in cats and are often surgically resectable. Feline
thyroid tumors are usually benign and hyperfunctionally leading to a
clinical syndrome of hyperthyroidism. Digital metastasis of primary lu
ng carcinomas causes lameness in cats, but has not been reported in do
gs. The vast majority of breast cancers in cats are malignant. Basal c
ell tumors represent a large percentage of melanotic tumors and lympho
ma is the most common spinal tumor of cats. In contrast to canine oste
osarcoma, appendicular osteosarcoma in cats is often curable with limb
amputation. An appreciation of these differences is critical so that
clinicians may accurately communicate prognostic information and treat
ment recommendations to their clients.