CLINICAL COURSE AND THERAPY OF CHRONIC MYELOGENOUS LEUKEMIA WITH INTERFERON-ALPHA AND CHEMOTHERAPY

Authors
KANTARJIAN HM GILES FJ OBRIEN SM TALPAZ M
Citation
Hm. Kantarjian et al., CLINICAL COURSE AND THERAPY OF CHRONIC MYELOGENOUS LEUKEMIA WITH INTERFERON-ALPHA AND CHEMOTHERAPY, Hematology/oncology clinics of North America, 12(1), 1998, pp. 31
Citations number
230
Categorie Soggetti
Oncology,Hematology
Journal title
Hematology/oncology clinics of North America → ACNP
ISSN journal
08898588
Volume
12
Issue
1
Year of publication
1998
Database
ISI
SICI code
0889-8588(1998)12:1<31:CCATOC>2.0.ZU;2-S
Abstract
This article begins with a review of the natural history of chronic my elogenous leukemia (CML), with an emphasis on prognostic features. Cur rent standard therapy of CML with interferon-alpha based regimens, and interferon-alpha, in the context of allogenic stem cell transplantati on is then discussed. Finally, some potentially effective novel agents including homoharringtonine, decitabine, ATRA, and topotecan are desc ribed.