DEVELOPMENT OF OINTMENT FORMULATIONS PREPARED WITH ACHYROCLINE SATUREIOIDES SPRAY-DRIED EXTRACTS

Achyrocline satureioides spray-dried extracts, prepared with colloidal silicon dioxide, microcrystalline cellulose + colloidal silicon dioxi de (1:1), and beta-cyclodextrin + colloidal silicon dioxide (1:1), wer e incorporated in a glyceryl monostearate base. The influence of the s pray-drying adjuvants on the formulations' physical characteristics, s uch as spreading properties, oil indexes, viscosities, and the pH dete rmination, were evaluated. The results indicated that the adjuvants in fluenced the ointments' physical parameters at different levels, altho ugh all of them maintained their plastic flow and presented antithixot ropic behavior. The presence of colloidal silicon dioxide alone, in th e dried extract, imparted the lowest oil index value and an intermedia ry spreading area to the ointment. The colloidal silicon dioxide conte nt reduction and the substitution of part of it by beta-cyclodextrin o r microcrystalline cellulose enhanced the ointments' oil index values, while the best spreading area was reached by the ointment prepared wi th the spray-dried extract containing colloidal silicon dioxide and mi crocrystalline cellulose.