OMEPRAZOLE HAS NO EFFECT ON ACETAMINOPHEN KINETICS IN THE RAT

We investigated in the rat the effect of the H+/K+-ATPase inhibitor, o meprazole, on the kinetics of acetaminophen. Two groups of rats were t reated with either omeprazole 50 mg/kg/day or the vehicle for 7 days. On day seven, the pharmacokinetic parameters of acetaminophen clearanc e were determined in the conscious rat. Elimination rate constant, eli mination half life time, clearance and volume of distribution of aceta minophen were not disturbed by omeprazole. It is concluded that in the rat, omeprazole does not affect acetaminophen kinetics and, therefore , will not increase susceptibility to acetaminophen toxicity.