This article provides guidelines for pharmacotherapy to maximize sympt
om relief from allergic rhinitis. Consideration of frequency severity,
and site of symptoms is important in directing pharmacotherapy effica
cy and maximizing cost-effectiveness. The agents available include ant
ihistamines, decongestants, steroids, mast cell stabilizers, anticholi
nergic agents, and mucolytics. Appropriate indications for each and co
mbinations of various agents are discussed within the context of drug
efficacy side effects, affordability, and ease of compliance. The dire
ct and indirect costs of allergic rhinitis are not well delineated but
are explored to put the costs of therapy in perspective.