PORTAL AND SPLANCHNIC HEMODYNAMICS IN PATIENTS WITH ADVANCED POSTHEPATITIC CIRRHOSIS AND IN HEALTHY-ADULTS - ASSESSMENT WITH DUPLEX-DOPPLERULTRASOUND

Purpose: To assess portal and splanchnic haemodynamics, and splanchnic vascular resistance in patients with advanced post-hepatitic cirrhosi s and in healthy volunteers, by means of duplex Doppler ultrasound (US ). Material and Methods: The duplex Doppler US examination was perform ed in 16 patients with cirrhosis and in 24 healthy volunteers. We inve stigated vessel diameters, mean flow velocities, and mean blood flows in the portal vein, the superior mesenteric artery (SMA), and the sple nic artery (SA), and measured the resistive index values of SMA and SA . Results: The mean portal venous blood flow in patients with cirrhosi s (829+/-264 ml/min) was not statistically different from those in the volunteers (734+/-194 ml/min). The ratio of the SMA and SA blood flow s (621 ml/min) to the portal venous blood flow (734 ml/min) was 0.85 i n the control subjects. The mean portal venous blood flow (1 261 ml/mi n) and the portal venous velocity (14.6 cm/s) were higher in the patie nts with recanalized para-umbilical veins than in the volunteers and i n the patients without recanalized para-umbilical veins. The SMA and S A blood flows were significantly increased in patients with cirrhosis compared with volunteers. Splanchnic inflow (the sum of the SMA and SA . blood flows) was higher than the portal blood flow in patients with cirrhosis except in the subjects with recanalized para-umbilical veins . SMA and SA resistive index values were significantly higher in these patients than in the volunteers. Conclusion: Splanchnic blood how and splanchnic vascular impedance increased significantly in patients wit h advanced post-hepatitic cirrhosis. Splanchnic inflow must not exceed portal venous blood flow in patients with recanalized para-umbilical veins. Portal vein velocity and portal venous blood flow measurements alone are not useful parameters for discriminating patients with cirrh osis from healthy subjects.