Objective: To investigate factors that determine the feasibility and e
ffectiveness of a critiquing system for asthma/COPD that will be integ
rated with a general practitioner's (GP's) information system. Design:
A simulation study. Four reviewers, playing the role of the computer,
generated critiquing comments and requests for additional information
an six electronic medical records of patients with asthma/COPD. Three
GPs who treated the patients, playing users, assessed the comments an
d provided missing information when requested. The GPs were asked why
requested missing information was unavailable. The reviewers reevaluat
ed their comments after receiving requested missing information, Measu
rements: Descriptions of the number and nature of critiquing comments
and requests for missing information. Assessment by the GPs of the cri
tiquing comments in terms of agreement with each comment and judgment
of its relevance, both on a five-point scale. Analysis of causes for t
he (un-)availability of requested missing information. Assessment of t
he impact of missing information on the generation of critiquing comme
nts. Results: Four reviewers provided 74 critiquing comments on 87 vis
its in six medical records. Most were about prescriptions (n = 28) and
the GPs' workplans (n = 27). The GPs valued comments about diagnostic
s the most. The correlation between the GPs' agreement and relevance s
cores was 0.65. However, the GPs' agreements with prescription comment
s (complete disagreement, 31.3%; disagreement, 20.0%; neutral, 13.8%;
agreement, 17.5%; complete agreement, 17.5%) differed from their judgm
ents of these comments' relevance (completely irrelevant, 9.0%; irrele
vant, 24.4%; neutral, 24.4%; relevant, 32.1%; completely relevant, 10.
3%). The GPs were able to provide answers to 64% of the 90 requests fo
r missing information. Reasons available information had not been reco
rded were: the GPs had not recorded the information explicitly; they h
ad assumed it to be common knowledge; it was available elsewhere in th
e record. Reasons information was unavailable were: the decision had b
een made by another; the GP had not recorded the information. The revi
ewers left 74% of the comments unchanged after receiving requested mis
sing information. Conclusion: Human reviewers can generate comments ba
sed on information currently available in electronic medical records o
f patients with asthma/COPD. The GPs valued comments regarding rite di
agnostic process the most. Although they judged prescription comments
relevant, they often strongly disagreed with them, a discrepancy that
poses a challenge for the presentation of critiquing comments for the
future critiquing system. Requested additional information that was pr
ovided by the GPs led to few changes. Therefore, as system developers
faced with the decision to build an integrated, non-inquisitive or an
inquisitive critiquing system, the authors choose the former.