IN-VITRO SUSCEPTIBILITY OF STAPHYLOCOCCUS-AUREUS ISOLATED FROM BLOOD TO CURRENTLY USED ANTISTAPHYLOCOCCAL DRUGS

Changes in antibiotic susceptibility was evaluated in 77 consecutive n osocomial clinical isolates of Staphylococcus aureus collected from 19 86 to 1994 at the Umberto I Polyclinic of the University of Rome (63 i solates) and from 7 other Roman hospitals (14 isolates). Oxacillin res istance in these isolates increased from 39% during the 1980s to 69% d uring the 1990s. Significant increases in resistance to ciprofloxacin, clindamycin and rifampicin were observed among oxacillin-resistant st rains. No resistance to glycopeptides was observed although both teico planin and vancomycin had slightly reduced antistaphylococcal activity .