UP-REGULATION OF NMDA RECEPTOR SUBUNIT PROTEINS IN THE CEREBRAL-CORTEX DURING DIAZEPAM WITHDRAWAL

Authors
TSUDA M CHIBA Y SUZUKI T MISAWA M
Citation
M. Tsuda et al., UP-REGULATION OF NMDA RECEPTOR SUBUNIT PROTEINS IN THE CEREBRAL-CORTEX DURING DIAZEPAM WITHDRAWAL, European journal of pharmacology, 341(2-3), 1998, pp. 1-2
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
341
Issue
2-3
Year of publication
1998
Pages
1 - 2
Database
ISI
SICI code
0014-2999(1998)341:2-3<1:UONRSP>2.0.ZU;2-R
Abstract
The present study investigated the changes in NMDA receptor subunit pr oteins in diazepam-withdrawn rat cerebral cortex, using Western blotti ng analysis. The protein levels of the NR1 and NR2B, but not NR2A, sub units were significantly increased in diazepam-withdrawn rats compared to those in control rats. Therefore, an increase in the NR1 and NR2B subunit proteins may be responsible for both the previously observed u pregulation of [H-3]dizocilpine binding in the cerebral cortex and the appearance of diazepam withdrawal signs. (C) 1998 Elsevier Science B. V.