L. Eriksson et al., LUNG TRANSPLANTATION AT THE UNIVERSITY-OF-LUND 1990-1995 - ANALYSIS OF THE FIRST 39 CONSECUTIVE PATIENTS, SC CARDIOVA, 32(1), 1998, pp. 23-28
Between 1990 and 1995 39 patients were lung transplanted at the Univer
sity Hospital in Lund. This is a retrospective review of survival and
lung function in these patients. There were 17 single-lung transplants
(SLT), 21 double-lung transplants (DLT) and 1 heart-lung transplant (
HLT). Seven patients died during the period, giving an overall surviva
l of 82%. One-year survival according to Kaplan-Meier survival analysi
s was 87%, and 2-year survival was 83%. Vital capacity and forced expi
ratory volume in 1 s (FEV1) 1 year after transplantation were 91% and
100% of predicted, respectively, in the DLT group and 60% and 50% in t
he SLT group. Bronchiolitis obliterans syndrome (BOS) developed in 11
of the 35 patients (31%) surviving more than 6 months, 2/21 in the DLT
group and 8/13 in the SLT group and in the patient with HLT. The medi
an time until detection of BOS was 11 months after the operation (rang
e 6-18 months). Working capacity 1 year after transplantation was 60%
of predicted in the DLT group and 47% of predicted in the SLT group. V
entilatory capacity was no longer function limiting. Lung transplantat
ion today is a therapeutic option with a good medium-term survival and
good functional results in selected patients with severe lung disease
.