EFFECTS OF HEMOPERFUSION ON SELECTED INDEXES OF BLOOD BIOCHEMISTRY INSHEEP

Citation
H. Seidel et al., EFFECTS OF HEMOPERFUSION ON SELECTED INDEXES OF BLOOD BIOCHEMISTRY INSHEEP, ACT VET B, 66(4), 1997, pp. 213-218
Citations number
26
Journal title
ACTA VETERINARIA BRNO
ISSN journal
00017213 → ACNP
Volume
66
Issue
4
Year of publication
1997
Pages
213 - 218
Database
ISI
SICI code
0001-7213(1997)66:4<213:EOHOSI>2.0.ZU;2-F
Abstract
The aim of this work was to evaluate the clinoptilolite as a cartridge for haemoperfusion columns. Changes in haematological indices and blo od plasma macro-elements were evaluated during haemoperfusion in sheep with the use of zeolitic and commercial haemoperfusion columns. Haemo perfusions were done in two groups of sheep (n=6) for 2 hours, In the first group, commercial haemoperfusion columns HEMASORB 400 C filled w ith active charcoal were used. In the second group, the columns used w ere filled with sodium form of natural zeolite-clinoptilolite partiall y saturated with potassium chloride. During 2 hours of haemoperfusion significant decrease in numbers of leukocytes and thrombocytes (P<0.01 ) were found in both types of columns. There were no significant diffe rences between the groups, except for the number of thrombocytes and p lasma sodium concentration in the blood leaving the zeolitic columns w ith significantly lower values after 30 min (134.3+/-28.9 vs. 251.0+/- 55.4 G.l(-1), P<0.01; and 144.17+/-9.13 vs. 157.17+/-7.36 mmol.l(-1), P<0.05; respectively) compared with commercial HEMASORB columns. Howev er, final evaluation of biocompatibility of zeolitic haemoperfusion co lumns will require more detailed research.