EFFECTS OF HEMOPERFUSION ON SELECTED INDEXES OF BLOOD BIOCHEMISTRY INSHEEP

The aim of this work was to evaluate the clinoptilolite as a cartridge for haemoperfusion columns. Changes in haematological indices and blo od plasma macro-elements were evaluated during haemoperfusion in sheep with the use of zeolitic and commercial haemoperfusion columns. Haemo perfusions were done in two groups of sheep (n=6) for 2 hours, In the first group, commercial haemoperfusion columns HEMASORB 400 C filled w ith active charcoal were used. In the second group, the columns used w ere filled with sodium form of natural zeolite-clinoptilolite partiall y saturated with potassium chloride. During 2 hours of haemoperfusion significant decrease in numbers of leukocytes and thrombocytes (P<0.01 ) were found in both types of columns. There were no significant diffe rences between the groups, except for the number of thrombocytes and p lasma sodium concentration in the blood leaving the zeolitic columns w ith significantly lower values after 30 min (134.3+/-28.9 vs. 251.0+/- 55.4 G.l(-1), P<0.01; and 144.17+/-9.13 vs. 157.17+/-7.36 mmol.l(-1), P<0.05; respectively) compared with commercial HEMASORB columns. Howev er, final evaluation of biocompatibility of zeolitic haemoperfusion co lumns will require more detailed research.