DEHYDROEPIANDROSTERONE-SULFATE TREATMENT OF MICE MODULATES INFECTION WITH SCHISTOSOMA-MANSONI

Authors
FALLON PG RICHARDSON EJ JONES FM DUNNE DW
Citation
Pg. Fallon et al., DEHYDROEPIANDROSTERONE-SULFATE TREATMENT OF MICE MODULATES INFECTION WITH SCHISTOSOMA-MANSONI, Clinical and diagnostic laboratory immunology, 5(2), 1998, pp. 251-253
Citations number
13
Categorie Soggetti
Immunology,"Infectious Diseases",Microbiology
Journal title
Clinical and diagnostic laboratory immunology → ACNP
ISSN journal
1071412X
Volume
5
Issue
2
Year of publication
1998
Pages
251 - 253
Database
ISI
SICI code
1071-412X(1998)5:2<251:DTOMMI>2.0.ZU;2-3
Abstract
Female mice treated with dehydroepiandrosterone sulfate early during i nfection were partially protected (P < 0.05-0.005) from Schistosoma ma nsoni infection. Hormone treatment did not modify parasite-specific ce llular or humoral responses. Serum dehydroepiandrosterone sulfate leve ls and testosterone infection were negatively correlated, r = -0.621 a nd r = -0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate -treated female mice may be due to the known antischistosomular activi ty of testosterone.