ANALYSIS OF THE MYOGLOBIN GENE IN HEART-DISEASE

Analysis of the myoglobin gene from a large number of patients with ca rdiac disease disclosed a single substantive mutation. However, no evi dence of biochemical or physiological dysfunction due to this mutation was defected. We conclude that, within the limits of presently availa ble techniques, myoglobin mutations are unlikely to contribute substan tially to the genotypic background of cardiac disease in the general p opulation. (C) 1997 Wiley-Liss, Inc.