THE EPH FAMILY RECEPTORS AND LIGANDS

The Eph family is the largest of all known tyrosine kinase receptor-li gand systems, They are expressed in distinct, but overlapping, spatial and temporal patterns during embryonic development and postnatal life , and function in a variety of morphogenic events, The best known func tion is their role in the guidance of migration of axons and cells in the nervous system through repulsive interactions. They may also play a role in angiogenesis, tissue patterning, and tumor formation. (C) 19 98 Elsevier Science Inc.