MODELING STRATEGIES FOR ENANTIOMERS SEPARATION BY SMB CHROMATOGRAPHY

Citation
Ls. Pais et al., MODELING STRATEGIES FOR ENANTIOMERS SEPARATION BY SMB CHROMATOGRAPHY, AIChE journal, 44(3), 1998, pp. 561-569
Citations number
39
Categorie Soggetti
Engineering, Chemical
Journal title
ISSN journal
00011541
Volume
44
Issue
3
Year of publication
1998
Pages
561 - 569
Database
ISI
SICI code
0001-1541(1998)44:3<561:MSFESB>2.0.ZU;2-9
Abstract
Modeling strategies for simulated moving bed adsorbers were studied to compare the simulated moving bed model (SMB) that considers the real shift of the injection and collection points to the true moving bed ap proach (TMB) that considers liquid and solid flow in opposite directio ns. The prediction of these two models is compared in terms of steady- state performance, steady-state internal concentration profiles, and t ransient behavior of the extract and raffinate purities. The influence of the degree of subdivision of the bed in the SMB model predictions is also analyzed and compared with the TMB performance. Model results are compared with experimental results obtained for the chromatographi c separation of binaphthol enantiomers.