LUNG HYPOPLASIA - A POSSIBLE TERATOGENIC EFFECT OF VALPROATE - CASE-REPORT

Three cases of lung hypoplasia occurring in two siblings and in an unr elated child are reported. All three cases had been exposed to valproa te in utero. The two female siblings had no other malformations, where as the third female had a number of defects consistent with the fetal valproate syndrome. Thus, none of the known major causes of lung hypop lasia was present in any of the three cases. It is discussed whether p ulmonary hypoplasia may be a separate disease entity or caused by pren atal exposure to valproate.