Gd. Brown et al., HYDROXYAPATITE CEMENT IMPLANT FOR REGENERATION OF PERIODONTAL OSSEOUSDEFECTS IN HUMANS, Journal of periodontology, 69(2), 1998, pp. 146-157
A NEWLY DEVELOPED CALCIUM PHOSPHATE cement used to promote bone regene
ration in craniofacial defects was examined to determine its potential
for treatment of periodontal osseous defects. Sixteen patients with m
oderate to severe periodontal disease and 2 bilaterally similar vertic
al bony defects received initial therapy including scaling and root pl
aning followed by treatment with either calcium phosphate cement, flap
curettage (F/C) or debridement plus demineralized freeze-dried bone a
llograft (DFDBA). Standardized radiographs were exposed at baseline an
d 12 months postsurgery for computer assisted densitometric image anal
ysis (CADIA). The extent of the bony defect was determined during init
ial and 12 month re-entry surgery. Within 6 months of implant placemen
t, 11 of 16 patients treated with calcium phosphate cement exfoliated
all or most of the implant through the gingival sulcus. At all 16 test
sites, a narrow radiolucent gap formed by 1 month postsurgery at the
initially tight visual interface between the radiopaque calcium phosph
ate cement and the walls of the bony defect. Mean probing depth reduct
ion and clinical attachment gain at sites treated with calcium phospha
te cement were 1.6 mm and 1.3 mm, respectively at 1 year. Minimal bony
defect fill was accompanied by mean crestal resorption of 1.4 mm. Alv
eolar crestal resorption at sites with calcium phosphate cement was st
atistically significant (P = 0.001). These findings contrasted with th
e more favorable outcomes for controls treated with DFDBA or F/C. DFDB
A sites exhibited probing depth reduction of 3.1 mm, clinical attachme
nt gain of 2.9 mm, and defect fill of 2.4 mm. Respective clinical chan
ges at F/C sites were 2.4 mm, 1.4 mm, and 1.1 mm. CADIA revealed clini
cally significant trends between the three treatment modalities at var
ious areas-of-interest, Based on the findings of this study, there is
no rationale available to support the use of hydroxyapatite cement imp
lant in its current formulation for the treatment of vertical intrabon
y periodontal defects.