DISPOSITION KINETICS OF MEBENDAZOLE IN PLASMA, MILK AND RUMINAL FLUIDOF GOATS

The experiment was designed to study the kinetics of mebendazole (MBZ) after single dose i.v. (5 mg/kg) and oral (40 mg/kg) administration i n two separate groups of six Black Bengal female goats in each group. The plasma half-life (t(1/2 beta)) and total body clearance (CLB) calc ulated after an i.v. dose were 23.15 +/- 6.71 h and 0.11 +/- 0.04 ml k g(-1) min(-1), respectively. The peak MBZ concentrations in plasma (C- pmax) of 5.80 +/- 0.88 and 6.10 +/- 0.56 mu g/ml, milk (C-mmax) of 10. 05 +/- 0.80 mu g/ml and ruminal fluid (C-Rmax) of 40.10 +/- 1.80 mu g/ ml after single-dose oral administration were obtained at t(max) of 2 and 12, 12 and 4 h, respectively. The plasma half-life (t(1/2 beta)) a nd total body clearance tate (CLB) determined after an oral dose were 14.71 +/- 0.84 h and 26.65 +/- 15.55 ml kg(-1) min(-1), respectively. The secondary peaks observed after i.v. and oral drug administrations during the elimination phase of plasma concentration time-curve sugges ted enterohepatic circulation of MBZ. The study indicated a dose of 5 mg/kg body weight MBZ orally to be repeated at an interval of 24 h in goats. (C) 1998 Published by Elsevier Science Ltd.